Anti-Rad21 antibody,Abcam,AB154769

What is this antibody validated in? Anti-Rad21 antibody (ab154769) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of Rad21? Anti-Rad21 (ab154769) specifically detects a band for Rad21 (UniProt: O60216) at a molecular weight of 72kDa. Trusted by the scientific community Anti-Rad21 (ab154769) was first used in a scientific publication in 2012 and has been cited over 20 times in peer-reviewed journals.

Host

Rabbit

Reactivity

Mouse, Human, Rat

Application

ICC/IF, IP, WB, IHC-P

Platform ID

BAB201202670

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Rad21 antibody
Cat. No.AB154769
HostRabbit
IsotypeIgG
ReactivityMouse, Human, Rat
ApplicationICC/IF, IP, WB, IHC-P
ClonalityPolyclonal
Concentration0.38 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human RAD21 aa 1-400. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Double-strand-break repair protein rad21 homolog. As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed : 11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed : 11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed : 25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).. 64-kDa C-terminal product. May promote apoptosis. See full target information RAD21

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