Anti-Rad21 antibody,Abcam,AB992

Product Specifications Anti-Rad21 antibody (ab992) is a rabbit polyclonal antibody and is validated for use in IP, WB in human, mouse samples. Anti-Rad21 antibody (ab992) specifically detects Rad21 (UniProt ID: O60216; Molecular weight: 72kDa) and is sold in 50 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-Rad21 antibody (ab992) has high sensitivity and specificity. Anti-Rad21 antibody (ab992) has been cited over 207 times in peer reviewed journals and is trusted by the scientific community. Anti-Rad21 antibody (ab992) has 21 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone - ab251568 .

Host

Rabbit

Reactivity

Mouse, Human

Application

IP, WB

Platform ID

BAB513708917

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Rad21 antibody
Cat. No.AB992
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationIP, WB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human RAD21 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 - 8 Preservative: 0.1% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Double-strand-break repair protein rad21 homolog. As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions (PubMed : 11509732). The cohesin complex may also play a role in spindle pole assembly during mitosis (PubMed : 11590136). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter (PubMed : 25575569). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).. 64-kDa C-terminal product. May promote apoptosis. See full target information RAD21

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