Anti-Rag A antibody,Abcam,AB128196

Target data Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed : 20381137, PubMed : 24095279, PubMed : 25936802, PubMed : 31601708, PubMed : 31601764, PubMed : 38103557). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form : RagA/RRAGA is in its active form when GTP-bound RagA/RRAGA forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagA/RRAGA heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed : 20381137, PubMed : 24095279, PubMed : 25936802, PubMed : 31601708, PubMed : 31601764, PubMed : 32868926). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed : 20381137, PubMed : 25936802, PubMed : 31601708, PubMed : 31601764). Involved in the RCC1/Ran-GTPase pathway (PubMed : 9394008). May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death (PubMed : 8995684).. (Microbial infection) May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. See full target information RRAGA