Anti-Respiratory Syncytial Virus Phosphoprotein antibody [RSVH102],Abcam,AB94965

Fusion partner: PS-NS/1-Ag4

Host

Mouse

Reactivity

Respiratory syncytial virus

Application

IP, WB, IHC-Fr, ICC/IF, ELISA

Platform ID

BAB143119299

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Respiratory Syncytial Virus Phosphoprotein antibody [RSVH102]
Cat. No.AB94965
HostMouse
IsotypeIgG1
ReactivityRespiratory syncytial virus
ApplicationIP, WB, IHC-Fr, ICC/IF, ELISA
ClonalityMonoclonal
Clone NumberRSVH102
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins (PubMed : 25568210, PubMed : 26474524). Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex (PubMed : 26474524). Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA (PubMed : 26474524). Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs (PubMed : 25568210). Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription (PubMed : 29489893). Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (By similarity). See full target information P

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