Anti-Respiratory Syncytial virus NS1 antibody [HL2383],Abcam,AB317212

Target data Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways (PubMed : 15047850). Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3 (PubMed : 15827150). Also disrupts the association of IRF3 with CREBBP (PubMed : 21632562). Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI (Probable) (PubMed : 22383950). Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction (PubMed : 30558248). Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C (PubMed : 17251292, PubMed : 23877405). The degradasome requires an intact mitochondrial MAVS (PubMed : 23877405). Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon (PubMed : 19625398). As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression (PubMed : 24480984, PubMed : 26557722). Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth (PubMed : 17151097). Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication (PubMed : 9445048). Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes (PubMed : 21533073). See full target information 1C