Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106],Abcam,AB125001
What is this antibody validated in? Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (ab125001) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of Retinoid X Receptor alpha/RXRA? Anti-Retinoid X Receptor alpha/RXRA [EPR7106] (ab125001) specifically detects a band for Retinoid X Receptor alpha/RXRA (UniProt: P19793) at a molecular weight of 51kDa. Trusted by the scientific community Anti-Retinoid X Receptor alpha/RXRA [EPR7106] (ab125001) was first used in a scientific publication in 2012 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Retinoid X Receptor alpha/RXRA antibody [EPR7106] (ab125001) has been confirmed by Western blot testing in RXRA Knockout HCT 116 cell line, ab273708 . Other related products We have a range of other formats of antibody clone [EPR7106] also available for your convenience: ab125001, HRP - ab200782 , Carrier free - ab232472 , PE - ab317892 , APC - ab317929 , Alexa Fluor® 488 - ab317969 , Alexa Fluor® 594 - ab318010 , Alexa Fluor® 555 - ab318052 , Alexa Fluor® 647 - ab318094 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, ICC/IF, IP
Platform ID
BAB143419155
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor for retinoic acid that acts as a transcription factor (PubMed : 10874028, PubMed : 11162439, PubMed : 11915042, PubMed : 37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed : 10195690, PubMed : 11162439, PubMed : 11915042, PubMed : 16107141, PubMed : 17761950, PubMed : 18800767, PubMed : 19167885, PubMed : 28167758, PubMed : 37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed : 10195690, PubMed : 11162439, PubMed : 11915042, PubMed : 17761950, PubMed : 28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed : 1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed : 20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed : 20215566, PubMed : 37478846, PubMed : 9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed : 10195690, PubMed : 11915042, PubMed : 28167758, PubMed : 29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed : 29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed : 10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed : 28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed : 28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed : 12145331, PubMed : 15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed : 26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed : 25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed : 30216632). See full target information RXRA
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- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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