Anti-Ribonuclease T2 antibody,Abcam,AB140191

Target data Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed : 31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed : 31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed : 31778653). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed : 28730546, PubMed : 30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed : 30385512). See full target information RNASET2