Anti-Ryanodine receptor 2/RYR-2 antibody [EPR26288-70],Abcam,AB302716

What is this antibody validated in? Anti-Ryanodine receptor 2/RYR-2 antibody [EPR26288-70] (ab302716) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr) in Human, Mouse, Rat samples. What is the molecular weight of Ryanodine receptor 2/RYR-2? Anti-Ryanodine receptor 2/RYR-2 [EPR26288-70] (ab302716) specifically detects a band for Ryanodine receptor 2/RYR-2 (UniProt: Q92736) at a molecular weight of 565kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR26288-70] also available for your convenience: ab302716, Carrier free - ab302717 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

IHC-P, IHC-Fr, WB, IP

Platform ID

BAB899591191

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Ryanodine receptor 2/RYR-2 antibody [EPR26288-70]
Cat. No.AB302716
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationIHC-P, IHC-Fr, WB, IP
ClonalityMonoclonal
Clone NumberEPR26288-70
Concentration0.53 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. See full target information RYR2

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