Anti-S100 antibody [4C4.9],Abcam,AB4066
This product was changed from ascites to tissue culture supernatant on 29/01/2021. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team. Product Specifications Anti-S100 antibody [4C4.9] (ab4066) is a mouse monoclonal antibody and is validated for use in IHC-P in human samples. Anti-S100 antibody [4C4.9] (ab4066) specifically detects S100 (UniProt ID: P23297; Molecular weight: 11kDa) and is sold in 500 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-S100 antibody [4C4.9] (ab4066) has high sensitivity and specificity. Anti-S100 antibody [4C4.9] (ab4066) has been cited over 87 times in peer reviewed journals and is trusted by the scientific community. Anti-S100 antibody [4C4.9] (ab4066) has 11 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone 4C4.9 - ab176243 .
Host
Mouse
Reactivity
Human
Application
IHC-P
Platform ID
BAB774828577
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed : 12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed : 23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed : 22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed : 12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed : 11717446). See full target information S100A1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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