Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker,Abcam,AB52642
Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-Fr IHC-P and WB. Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) was first used in a scientific publication in 2009 and has been cited over 399 times in peer reviewed journals. It's performance in IHC in mouse and human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) has 35 independent reviews from customers. Anti-S100 beta antibody [EP1576Y] - Astrocyte Marker (ab52642) specifically detects S100 beta (UniProt ID: P04271; Molecular weight: 11kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EP1576Y - ab215989 . Antibody clone EP1576Y is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor ® 647, Alexa Fluor ® 594, Alexa Fluor ® 488, Alexa Fluor ® 555, Alexa Fluor ® 568 ( ab195535 , ab196175 , ab307851 , ab310990 , ab313219 , ab313817 ). S100B is a calcium-binding protein widely used in neuro research, particularly for its role as a biomarker in neurological diseases. It is expressed in glial cells and certain neurons and its levels can indicate brain injury and neuroinflammation. Researchers use S100B to assess glial activation and neuronal damage in conditions such as traumatic brain injury, stroke and neurodegenerative diseases (e.g. Alzheimer's disease). This makes S100B essential for understanding the extent of brain damage and the inflammatory response in various neurological disorders. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, ICC/IF, WB, IHC-Fr
Platform ID
BAB899891047
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed : 20950652, PubMed : 6487634). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed : 20950652, PubMed : 6487634). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed : 20351179). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed : 22399290). See full target information S100B
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- Products>Primary Antibodies>Monoclonal Antibodies
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