Anti-S100A4 antibody [EPR14639(2)],Abcam,AB197896
Product Specifications Anti-S100A4 antibody [EPR14639(2)] (ab197896) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-S100A4 antibody [EPR14639(2)] (ab197896) specifically detects S100A4 (UniProt ID: P26447; Molecular weight: 12kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-S100A4 antibody [EPR14639(2)] (ab197896) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-S100A4 antibody [EPR14639(2)] (ab197896) has been confirmed by testing in knockout samples. Anti-S100A4 antibody [EPR14639(2)] (ab197896) has been cited over 62 times in peer reviewed journals and is trusted by the scientific community. Anti-S100A4 antibody [EPR14639(2)] (ab197896) has 8 independent reviews from customers. Related Products Antibody clone EPR14639(2) is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488 ( ab208566 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
Flow Cyt (Intra), IP, ICC/IF, IHC-P, WB
Platform ID
BAB837609692
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed : 16707441, PubMed : 23752197, PubMed : 30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed : 16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed : 23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed : 26654597, PubMed : 30713770). See full target information S100A4
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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