Anti-SARS CoV-2 ORF3a Protein antibody [EPR24848-9] - BSA and Azide free,Abcam,AB280961

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

SARS-CoV-2

Application

ELISA, WB, IHC-P, Flow Cyt (Intra), IP, ICC/IF

Platform ID

BAB964571250

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SARS CoV-2 ORF3a Protein antibody [EPR24848-9] - BSA and Azide free
Cat. No.AB280961
HostRabbit
IsotypeIgG
ReactivitySARS-CoV-2
ApplicationELISA, WB, IHC-P, Flow Cyt (Intra), IP, ICC/IF
ClonalityMonoclonal
Clone NumberEPR24848-9
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationConstituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays a role in viral egress via lysosomal trafficking (PubMed : 33157038, PubMed : 33422265). Forms homotetrameric ion channels (viroporins) localized at endosomes and lysosomes, that may induce deacidification of lysosomes, allowing safe egress of virions via lysosomal trafficking (PubMed : 33157038, PubMed : 33422265, PubMed : 34158638). Also blocks autolysosome formation by binding and sequestering the host component VPS39 for homotypic fusion and protein sorting (HOPS) on late endosomes (PubMed : 33422265). This prevents fusion of autophagosomes with lysosomes, disrupting autophagy and facilitating virus egress (PubMed : 33422265). Induces host RETREG1/FAM134B-dependent reticulophagy by interacting with host HMGB1 and enhancing the association between HMGB1 and host BECN1 (PubMed : 35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed : 35239449). See full target information 3a Additional targets SARS CoV-2 ORF3a Protein

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