Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal,Abcam,AB51502

This product was changed from ascites to tissue culture supernatant on 9 th August 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team. Product Specifications Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) is a mouse monoclonal antibody and is validated for use in ICC, IP, WB in human, mouse samples. Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) specifically detects SATB1 +SATB2 (UniProt ID: Q01826; Molecular weight: 86kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has high sensitivity and specificity. The specificity of Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has been confirmed by testing in knockout samples. Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has been cited over 314 times in peer reviewed journals and is trusted by the scientific community. Anti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal (ab51502) has 17 independent reviews from customers.

Host

Mouse

Reactivity

Mouse, Human

Application

WB, ICC, IP

Platform ID

BAB777827137

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SATB1 + SATB2 antibody [SATBA4B10] - C-terminal
Cat. No.AB51502
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationWB, ICC, IP
ClonalityMonoclonal
Clone NumberSATBA4B10
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human SATB2. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: 1% BSA, 0.812% Sodium chloride, 0.1136% Disodium hydrogenorthophosphate, 0.0225% Potassium chloride, 0.0204% Potassium phosphate monobasic
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. See full target information SATB2 Additional targets SATB1

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