Anti-SCN4A antibody,Abcam,AB138079

Target data Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed : 12766226, PubMed : 15318338, PubMed : 16890191, PubMed : 17898326, PubMed : 18690054, PubMed : 19347921, PubMed : 25707578, PubMed : 26659129, PubMed : 26700687, PubMed : 29992740, PubMed : 30190309). Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction (PubMed : 16890191, PubMed : 19347921, PubMed : 25707578, PubMed : 26659129, PubMed : 26700687). See full target information SCN4A