Anti-SDHA antibody [2E3GC12FB2AE2],Abcam,AB14715

Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) is a House Mouse Monoclonal antibody and is validated for use in Flow Cyt, ICC, IHC-Fr, IHC-P, WB in human, rat samples. Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has been cited over 460 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality validation processes ensure Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has high sensitivity and specificity. The specificity of Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has been confirmed by testing in knockout samples. Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) has 23 independent reviews from customers. Anti-SDHA antibody [2E3GC12FB2AE2] (ab14715) specifically detects SDHA (UniProt ID: P31039; Molecular weight: 68kDa) and is sold in 100 ug selling sizes. Antibody clone 2E3GC12FB2AE2 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 594, HRP ( ab154473 , ab17172, ab198493 ). SDHA (FP), a subunit of succinate dehydrogenase, is a crucial mitochondrial enzyme involved in the Krebs cycle and electron transport chain. The SDHA molecular weight is approximately 72 kDa, and it plays a vital role in cellular energy production. The FP antibody is essential for studying SDHA's function and its role as a tumor suppressor. Abnormal SDHA levels are linked to various diseases, including hereditary paragangliomas, pheochromocytomas, and certain cancers. Monitoring SDHA can provide valuable insights into disease mechanisms and potential therapeutic targets. Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Mouse, Rat, Cow, Human

Application

WB, IHC-P, ICC, IHC-Fr, Flow Cyt

Platform ID

BAB904089031

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-SDHA antibody [2E3GC12FB2AE2]
Cat. No.AB14715
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Cow, Human
ApplicationWB, IHC-P, ICC, IHC-Fr, Flow Cyt
ClonalityMonoclonal
Clone Number2E3GC12FB2AE2
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Preservative: 0.02% Sodium azide Constituents: HEPES buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed : 10746566, PubMed : 24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed : 20484225). See full target information SDHA

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.