Anti-SDHB antibody [21A11AE7],Abcam,AB14714

Product Specifications Anti-SDHB antibody [21A11AE7] (ab14714) is a mouse monoclonal antibody and is validated for use in Flow Cyt, ICC/IF, IHC-Fr, WB in cow, human, mouse, rat samples. Anti-SDHB antibody [21A11AE7] (ab14714) specifically detects SDHB (UniProt ID: P21912; Molecular weight: 29kDa) and is sold in 100 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-SDHB antibody [21A11AE7] (ab14714) has high sensitivity and specificity. The specificity of Anti-SDHB antibody [21A11AE7] (ab14714) has been confirmed by testing in knockout samples. Anti-SDHB antibody [21A11AE7] (ab14714) has been cited over 276 times in peer reviewed journals and is trusted by the scientific community. Anti-SDHB antibody [21A11AE7] (ab14714) has 12 independent reviews from customers. Related Products Antibody clone 21A11AE7 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 488, HRP ( ab197722 , ab197902 , ab197903 ). Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Mouse, Rat, Cow, Human

Application

Flow Cyt, WB, IHC-Fr, ICC/IF

Platform ID

BAB029151501

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-SDHB antibody [21A11AE7]
Cat. No.AB14714
HostMouse
IsotypeIgG2a
ReactivityMouse, Rat, Cow, Human
ApplicationFlow Cyt, WB, IHC-Fr, ICC/IF
ClonalityMonoclonal
Clone Number21A11AE7
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.5 Preservative: 0.02% Sodium azide Constituents: HEPES buffered saline
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed : 26925370, PubMed : 27604842). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). See full target information SDHB

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