Anti-SGF29 antibody - N-terminal,Abcam,AB204367

Host

Rabbit

Reactivity

Human

Application

IHC-P, ICC/IF

Platform ID

BAB594581344

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SGF29 antibody - N-terminal
Cat. No.AB204367
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, ICC/IF
ClonalityPolyclonal
Concentration0.1 - 0.3 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human SGF29 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed : 19103755, PubMed : 20850016, PubMed : 21685874, PubMed : 26421618, PubMed : 26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed : 20850016, PubMed : 21685874, PubMed : 26421618, PubMed : 26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed : 20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed : 23894581). Also binds non-histone proteins that are methylated on Lys residues : specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity). See full target information SGF29

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