Anti-SH3BP5 antibody,Abcam,AB222860

Host

Rabbit

Reactivity

Mouse, Human

Application

ICC/IF, IHC-P, WB

Platform ID

BAB719943670

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SH3BP5 antibody
Cat. No.AB222860
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationICC/IF, IHC-P, WB
ClonalityPolyclonal
Concentration3 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human SH3BP5 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed : 26506309, PubMed : 30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. See full target information SH3BP5

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