Anti-SHP2 antibody [Y478],Abcam,AB32083
What is this antibody validated in? Anti-SHP2 antibody [Y478] (ab32083) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of SHP2? Anti-SHP2 [Y478] (ab32083) specifically detects a band for SHP2 (UniProt: Q06124) at a molecular weight of 68kDa. Trusted by the scientific community Anti-SHP2 [Y478] (ab32083) was first used in a scientific publication in 2006 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-SHP2 antibody [Y478] (ab32083) has been confirmed by Western blot testing in PTPN11 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [Y478] also available for your convenience: ab32083, Carrier free - ab182179 , Alexa Fluor® 594 - ab210616 , PE - ab305844 , APC - ab305845 , HRP - ab305846 , Alkaline Phosphatase - ab308735 , Alexa Fluor® 488 - ab309693 , Alexa Fluor® 647 - ab310059 , Alexa Fluor® 555 - ab311979 , Alexa Fluor® 568 - ab312453 , Alexa Fluor® 750 - ab321568 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
WB, IP, ICC/IF, Flow Cyt (Intra), IHC-P
Platform ID
BAB783224545
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed : 10655584, PubMed : 14739280, PubMed : 18559669, PubMed : 18829466, PubMed : 26742426, PubMed : 28074573, PubMed : 32184441). Positively regulates MAPK signal transduction pathway (PubMed : 28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed : 28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed : 18559669). Dephosphorylates CDC73 (PubMed : 26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed : 19275884). Acts as an effector of PDCD1-mediated inhibition of T-cell response : recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to TCR signaling inhibition (PubMed : 32184441). See full target information PTPN11
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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