Anti-SIRT3 antibody [EPR23514-36],Abcam,AB246522

Target data NAD-dependent protein deacetylase (PubMed : 17923681, PubMed : 18794531, PubMed : 21172655, PubMed : 23835326, PubMed : 26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed : 17923681, PubMed : 18794531, PubMed : 21172655, PubMed : 23835326). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed : 16790548, PubMed : 18794531, PubMed : 21172655). Contributes to the regulation of the cellular energy metabolism (PubMed : 23835326, PubMed : 36804859). Important for regulating tissue-specific ATP levels (PubMed : 18794531, PubMed : 24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed : 23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed : 26620563). Regulates hepatic lipogenesis (PubMed : 36804859). Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance (PubMed : 36804859). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by mediating delactylation of proteins, such as CCNE2 and 'Lys-16' of histone H4 (H4K16la) (By similarity). See full target information Sirt3