Anti-SLC13A5 antibody,Abcam,AB247057

Target data High-affinity sodium/citrate cotransporter that mediates the entry of citrate into cells, which is a critical participant of biochemical pathways (PubMed : 12445824, PubMed : 12826022, PubMed : 26324167, PubMed : 26384929, PubMed : 30054523, PubMed : 33597751). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed : 12826022). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed : 12445824, PubMed : 12826022, PubMed : 26324167, PubMed : 26384929, PubMed : 30054523, PubMed : 33597751). Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed : 26324167). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed : 12445824, PubMed : 12826022). Involved in the regulation of citrate levels in the brain (By similarity). See full target information SLC13A5