Anti-SLC5A7 antibody [EPR25152-16],Abcam,AB289635

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human, Mouse

Application

WB, Flow Cyt (Intra), ICC/IF

Platform ID

BAB848604412

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SLC5A7 antibody [EPR25152-16]
Cat. No.AB289635
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse
ApplicationWB, Flow Cyt (Intra), ICC/IF
ClonalityMonoclonal
Clone NumberEPR25152-16
Concentration0.518 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data High-affinity Na(+)-coupled choline transmembrane symporter (PubMed : 11027560, PubMed : 11068039, PubMed : 12237312, PubMed : 12969261, PubMed : 17005849, PubMed : 23132865, PubMed : 23141292, PubMed : 27569547). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (PubMed : 17005849). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (PubMed : 11068039, PubMed : 12237312, PubMed : 17005849). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (PubMed : 27569547). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (PubMed : 11027560). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (PubMed : 12969261, PubMed : 15953352). See full target information SLC5A7

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