Anti-SLCO1C1 antibody,Abcam,AB234729

Target data Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed : 12351693, PubMed : 18566113, PubMed : 19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed : 18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed : 18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed : 12351693, PubMed : 19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed : 19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed : 30296914). See full target information SLCO1C1