Anti-SLFN12 antibody [EPR20904-32],Abcam,AB234418

What is this antibody validated in? Anti-SLFN12 antibody [EPR20904-32] (ab234418) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-Fr) in Human samples. What is the molecular weight of SLFN12? Anti-SLFN12 [EPR20904-32] (ab234418) specifically detects a band for SLFN12 (UniProt: Q8IYM2) at a molecular weight of 67kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-SLFN12 antibody [EPR20904-32] (ab234418) has been confirmed by Western blot testing in SLFN12 Knockout HeLa cells. Other related products We have a range of other formats of antibody clone [EPR20904-32] also available for your convenience: ab234418, Carrier free - ab256300 , PE - ab317888 , APC - ab317925 , Alexa Fluor® 488 - ab317965 , Alexa Fluor® 594 - ab318006 , Alexa Fluor® 555 - ab318048 , Alexa Fluor® 647 - ab318090 , Alexa Fluor® 750 - ab321476 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human

Application

Flow Cyt (Intra), IHC-Fr, WB

Platform ID

BAB598879280

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-SLFN12 antibody [EPR20904-32]
Cat. No.AB234418
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationFlow Cyt (Intra), IHC-Fr, WB
ClonalityMonoclonal
Clone NumberEPR20904-32
Concentration0.753 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed : 31420216, PubMed : 34272366, PubMed : 34707099, PubMed : 35104454). May play a role in cell differentiation (PubMed : 30045019). See full target information SLFN12

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