Anti-SLFN14 antibody,Abcam,AB106406

Host

Rabbit

Reactivity

Mouse

Application

WB, ICC/IF

Platform ID

BAB536398021

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SLFN14 antibody
Cat. No.AB106406
HostRabbit
IsotypeIgG
ReactivityMouse
ApplicationWB, ICC/IF
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human Protein SLFN14. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Protein SLFN14. Shows no ribosome-associated and endoribonuclease activities.. C-terminally truncated SLFN14 endoribonuclease. Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed : 25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension. See full target information Protein SLFN14

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.