Anti-SOX2 antibody [20G5],Abcam,AB171380

What is this antibody validated in? Anti-SOX2 antibody [20G5] (ab171380) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples. What is the molecular weight of SOX2? Anti-SOX2 [20G5] (ab171380) specifically detects a band for SOX2 (UniProt: P48431) at a molecular weight of 34kDa. Trusted by the scientific community Anti-SOX2 [20G5] (ab171380) was first used in a scientific publication in 2013 and has been cited over 50 times in peer-reviewed journals.

Host

Mouse

Reactivity

Mouse, Human

Application

IHC-P, IP, Flow Cyt, ICC/IF, WB

Platform ID

BAB165708451

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-SOX2 antibody [20G5]
Cat. No.AB171380
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationIHC-P, IP, Flow Cyt, ICC/IF, WB
ClonalityMonoclonal
Clone Number20G5
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Mouse Sox2.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed : 18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). See full target information SOX2

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