Anti-SPG3A/ATL1 antibody [EPR28057-64],Abcam,AB316111

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Flow Cyt (Intra), WB, IHC-P, IP, ICC/IF, IHC-Fr

Platform ID

BAB791720465

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SPG3A/ATL1 antibody [EPR28057-64]
Cat. No.AB316111
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationFlow Cyt (Intra), WB, IHC-P, IP, ICC/IF, IHC-Fr
ClonalityMonoclonal
Clone NumberEPR28057-64
Concentration0.536 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (PubMed : 14506257, PubMed : 18270207, PubMed : 19665976, PubMed : 27619977, PubMed : 34817557, PubMed : 38509071). Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (PubMed : 14506257, PubMed : 21220294, PubMed : 21368113, PubMed : 23334294, PubMed : 38509071). May also regulate more or less directly Golgi biogenesis (PubMed : 17321752). Indirectly regulates axonal development (By similarity). See full target information ATL1

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