Anti-SREBP1 antibody [EPR27079-194],Abcam,AB313881
What is this antibody validated in? Anti-SREBP1 antibody [EPR27079-194] (ab313881) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse samples. What is the molecular weight of SREBP1? Anti-SREBP1 [EPR27079-194] (ab313881) specifically detects a band for SREBP1 (UniProt: Q9WTN3) at a molecular weight of 122kDa. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-SREBP1 antibody [EPR27079-194] (ab313881) has been confirmed by Western blot testing in Srebf1 Knockout HCT 116 cells. Other related products We have a range of other formats of antibody clone [EPR27079-194] also available for your convenience: ab313881, Carrier free - ab313882 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human, Mouse
Application
WB
Platform ID
BAB917982359
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Sterol regulatory element-binding protein 1. Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed : 11782483, PubMed : 12855691, PubMed : 19244231). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed : 11782483, PubMed : 12855691, PubMed : 16100574, PubMed : 19244231).. Processed sterol regulatory element-binding protein 1. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed : 17290224, PubMed : 19244231, PubMed : 21459323, PubMed : 9329978, PubMed : 9784493). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (By similarity). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed : 17290224, PubMed : 19244231, PubMed : 21459323, PubMed : 9329978, PubMed : 9784493).. Isoform SREBP-1A. Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (PubMed : 12855691, PubMed : 21531336). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed : 8833906). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (PubMed : 12855691, PubMed : 9062341). Required for innate immune response in macrophages by regulating lipid metabolism (PubMed : 21531336).. Isoform SREBP-1C. Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (PubMed : 12855691, PubMed : 21531336). Primarily controls expression of lipogenic gene (PubMed : 8833906, PubMed : 9062341). Strongly activates global lipid synthesis in rapidly growing cells (PubMed : 8833906, PubMed : 9062341). See full target information Srebf1
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- Products>Primary Antibodies>Monoclonal Antibodies
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