Anti-SREBP1 antibody [EPR27079-194] - BSA and Azide free,Abcam,AB313882
ab313882 is the carrier-free version of ab313881 . Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Conjugation ready Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold. Compatibility This product is compatible with the Maxpar ® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar ® is a trademark of Fluidigm Canada Inc.
Host
Rabbit
Reactivity
Human, Mouse
Application
WB
Platform ID
BAB230488606
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Sterol regulatory element-binding protein 1. Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed : 11782483, PubMed : 12855691, PubMed : 19244231). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed : 11782483, PubMed : 12855691, PubMed : 16100574, PubMed : 19244231).. Processed sterol regulatory element-binding protein 1. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis (PubMed : 17290224, PubMed : 19244231, PubMed : 21459323, PubMed : 9329978, PubMed : 9784493). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') (By similarity). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation (PubMed : 17290224, PubMed : 19244231, PubMed : 21459323, PubMed : 9329978, PubMed : 9784493).. Isoform SREBP-1A. Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C (PubMed : 12855691, PubMed : 21531336). Able to stimulate both lipogenic and cholesterogenic gene expression (PubMed : 8833906). Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver (PubMed : 12855691, PubMed : 9062341). Required for innate immune response in macrophages by regulating lipid metabolism (PubMed : 21531336).. Isoform SREBP-1C. Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A (PubMed : 12855691, PubMed : 21531336). Primarily controls expression of lipogenic gene (PubMed : 8833906, PubMed : 9062341). Strongly activates global lipid synthesis in rapidly growing cells (PubMed : 8833906, PubMed : 9062341). See full target information Srebf1
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