Anti-SREBP2 antibody,Abcam,AB30682

Product Specifications Anti-SREBP2 antibody (ab30682) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-Fr, WB in chicken, human, rat samples. Anti-SREBP2 antibody (ab30682) specifically detects SREBP2 (UniProt ID: Q12772; Molecular weight: 124kDa) and is sold in 250 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-SREBP2 antibody (ab30682) has high sensitivity and specificity. Anti-SREBP2 antibody (ab30682) has been cited over 165 times in peer reviewed journals and is trusted by the scientific community. Anti-SREBP2 antibody (ab30682) has 11 independent reviews from customers.

Host

Rabbit

Reactivity

Rat, Human

Application

IHC-Fr, WB, ICC/IF

Platform ID

BAB793019841

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-SREBP2 antibody
Cat. No.AB30682
HostRabbit
IsotypeIgG
ReactivityRat, Human
ApplicationIHC-Fr, WB, ICC/IF
ClonalityPolyclonal
Concentration0.4 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human SREBF2 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 50% Glycerol (glycerin, glycerine), 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Sterol regulatory element-binding protein 2. Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane (PubMed : 32322062). Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis (PubMed : 32322062).. Processed sterol regulatory element-binding protein 2. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis (PubMed : 12177166, PubMed : 32322062). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (PubMed : 12177166, PubMed : 7903453). Regulates transcription of genes related to cholesterol synthesis pathway (PubMed : 12177166, PubMed : 32322062). See full target information SREBF2

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