Anti-SRY/TDF antibody - N-terminal,Abcam,AB193174

Target data Transcriptional regulator that controls a genetic switch in male development (PubMed : 33004521). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed : 33004521). Involved in different aspects of gene regulation including promoter activation or repression (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed : 15170344, PubMed : 8159753, PubMed : 8190643). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).. Isoform Sry-T. Constitutes the major isoform, which is necessary and sufficient for initiating male sex determination.. Isoform Sry-S. Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation (PubMed : 33004521). Not necessary and sufficient for initiating male sex determination (PubMed : 33004521). See full target information Sry