Anti-STEAP4 antibody - N-terminal,Abcam,AB140951

Target data Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed : 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed : 18381574, PubMed : 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed : 19660107). Inhibits anchorage-independent cell proliferation (PubMed : 19787193). See full target information STEAP4