Anti-SV2A antibody,Abcam,AB32942

Target data Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.. (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds via extracellular loop 4 (PubMed : 16543415). Restores uptake of BoNT/A in mouse cells that are deleted for SV2 receptor (PubMed : 16543415, PubMed : 18815274). Glycosylation of Asn-573 is not essential for receptor activity, but enhances uptake (PubMed : 18815274, PubMed : 19650874). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed : 29649119).. Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E, nor to loop 1 or loop 3 (PubMed : 21483489). Another group does not find a convincing interaction with SV2 (PubMed : 21632541).. (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 and requires glycosylation of Asn-573 (PubMed : 18815274, PubMed : 19650874). Restores uptake of BoNT/E in mouse cells that are deleted for SV2 receptor (PubMed : 18815274).. (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F) (PubMed : 19476346, PubMed : 19650874). Binding requires glycosylation of Asn-573 (PubMed : 19476346). See full target information Sv2a