Anti-Semaphorin 4D/CD100 antibody [133-1C6],Abcam,AB288670

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Platform ID

BAB905088551

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Semaphorin 4D/CD100 antibody [133-1C6]
Cat. No.AB288670
HostMouse
IsotypeIgM
ReactivityHuman
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number133-1C6
ImmunogenCell preparation containing SEMA4D protein. The exact immunogen used to generate this antibody is proprietary information.
PurityMulti-step chromatography
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.098% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed : 20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed : 19788569). Promotes the migration of cerebellar granule cells (PubMed : 16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed : 8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed : 16055703). See full target information SEMA4D

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