Anti-Smac/Diablo antibody [SMAC 17 1-87],Abcam,AB111893

Host

Mouse

Reactivity

Mouse, Rat, Human

Application

IHC-P, WB, ICC/IF

Platform ID

BAB286872793

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Smac/Diablo antibody [SMAC 17 1-87]
Cat. No.AB111893
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Human
ApplicationIHC-P, WB, ICC/IF
ClonalityMonoclonal
Clone NumberSMAC 17 1-87
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Human DIABLO.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed : 15200957, PubMed : 36758104, PubMed : 36758105, PubMed : 36758106).. Isoform 3. Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation.. Isoform 1. Defective in the capacity to down-regulate the XIAP/BIRC4 abundance. See full target information DIABLO

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.