Anti-Smad2 antibody [5G7],Abcam,AB119907

This product was changed from ascites to supernatant. Lot no's high than GR163661-5 are from Tissue Culture Supernatant

Host

Mouse

Reactivity

Mouse, Human

Application

ELISA, ICC/IF, Flow Cyt, IHC-P, WB

Platform ID

BAB724541462

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Smad2 antibody [5G7]
Cat. No.AB119907
HostMouse
IsotypeIgG1
ReactivityMouse, Human
ApplicationELISA, ICC/IF, Flow Cyt, IHC-P, WB
ClonalityMonoclonal
Clone Number5G7
ImmunogenRecombinant Fragment Protein within Human SMAD2. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed : 8752209). See full target information SMAD2

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