Anti-Smad2 (phospho S467) antibody [EPR23681-40],Abcam,AB280888
What is this antibody validated in? Anti-Smad2 (phospho S467) antibody [EPR23681-40] (ab280888) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Dot Blot in Human, Mouse, Rat samples. What is the molecular weight of Smad2? Anti-Smad2 (phospho S467) [EPR23681-40] (ab280888) specifically detects a band for Smad2 (UniProt: Q15796) at a molecular weight of 52kDa. Trusted by the scientific community Anti-Smad2 (phospho S467) [EPR23681-40] (ab280888) was first used in a scientific publication in 2021 and has been cited over 20 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Smad2 (phospho S467) antibody [EPR23681-40] (ab280888) has been confirmed by Western blot testing in Smad2 Knockout HeLa cell line, ab255430 . Other related products We have a range of other formats of antibody clone [EPR23681-40] also available for your convenience: ab280888, Carrier free - ab280897 , APC - ab310849 , PE - ab310919 , Alexa Fluor® 488 - ab310951 , Alexa Fluor® 594 - ab311654 , Alexa Fluor® 555 - ab313140 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB, Flow Cyt (Intra), IP, ICC/IF, Dot
Platform ID
BAB599678896

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma (PubMed : 8752209). See full target information SMAD2 phospho S467
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