Anti-Sodium/Hydrogen Exchanger 1/NHE-1 antibody [4E9],Abcam,AB24018

Target data Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed : 11350981, PubMed : 11532004, PubMed : 14680478, PubMed : 15035633, PubMed : 15677483, PubMed : 17073455, PubMed : 17493937, PubMed : 22020933, PubMed : 27650500, PubMed : 32130622, PubMed : 7110335, PubMed : 7603840). Exchanges intracellular H(+) ions for extracellular Na(+) in 1 : 1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed : 12947095, PubMed : 15096511, PubMed : 22020933, PubMed : 8901634). In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter (PubMed : 7603840). SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (PubMed : 15096511). See full target information SLC9A1