Anti-Sodium Potassium ATPase antibody [EP1845Y] - Mouse IgG1 (Chimeric),Abcam,AB283318

This mouse monoclonal chimeric antibody has been engineered from a RabMAb parent antibody ( ab76020 ). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Mouse

Reactivity

Rat, Human, Mouse

Application

ICC/IF, IHC-P, Flow Cyt (Intra), WB

Platform ID

BAB289871353

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Sodium Potassium ATPase antibody [EP1845Y] - Mouse IgG1 (Chimeric)
Cat. No.AB283318
HostMouse
IsotypeIgG1
ReactivityRat, Human, Mouse
ApplicationICC/IF, IHC-P, Flow Cyt (Intra), WB
ClonalityMonoclonal
Clone NumberEP1845Y
Concentration0.979 mg/mL Batch dependent concentration
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed : 29499166, PubMed : 30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). See full target information ATP1A1

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