Anti-Sodium Potassium ATPase antibody [EP1845Y] - Rat IgG2a (Chimeric),Abcam,AB283345

This rat monoclonal chimeric antibody has been engineered from a RabMAb parent antibody ( ab76020 ). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rat

Reactivity

Mouse, Human, Rat

Application

WB, ICC/IF, Flow Cyt (Intra), IHC-P

Platform ID

BAB227390094

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Sodium Potassium ATPase antibody [EP1845Y] - Rat IgG2a (Chimeric)
Cat. No.AB283345
HostRat
IsotypeIgG2a
ReactivityMouse, Human, Rat
ApplicationWB, ICC/IF, Flow Cyt (Intra), IHC-P
ClonalityMonoclonal
Clone NumberEP1845Y
Concentration0.937 mg/mL Batch dependent concentration
PurityIon exchange chromatography
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed : 29499166, PubMed : 30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). See full target information ATP1A1

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