Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal,Abcam,AB134152

Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P and WB. Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) was first used in a scientific publication in 2008 and has been cited over 127 times in peer reviewed journals. It's performance in IHC in human samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal (ab134152) specifically detects Somatostatin Receptor 2 (UniProt ID: P30874; Molecular weight: 42kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone UMB1 - ab216649 . Antibody clone UMB1 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 647, Alexa Fluor ® 488, Alexa Fluor ® 594, Alexa Fluor ® 568, Alexa Fluor ® 555, Alexa Fluor ® 750 ( ab225183 , ab311039 , ab311816 , ab313099 , ab313292 , ab321081 ). Somatostatin Receptor 2 (SSTR2) is overexpressed in various tumors and plays a role in inhibiting tumor growth by mediating antiproliferative signals. It is also a target for diagnostic imaging and therapeutic interventions, particularly in neuroendocrine tumors. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

WB, IHC-P

Platform ID

BAB415133727

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Somatostatin Receptor 2 antibody [UMB1] - C-terminal
Cat. No.AB134152
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationWB, IHC-P
ClonalityMonoclonal
Clone NumberUMB1
Concentration1.856 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.5% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. See full target information SSTR2

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.