Anti-Steroidogenic Factor 1/SF-1 antibody [EPR19744],Abcam,AB217317
Product Specifications Anti-Steroidogenic Factor 1/SF-1 antibody [EPR19744] (ab217317) is a rabbit recombinant monoclonal antibody and is validated for use in ChIC/CUT&RUN-seq, IHC-P in human samples. Anti-Steroidogenic Factor 1/SF-1 antibody [EPR19744] (ab217317) specifically detects Steroidogenic Factor 1/SF-1 (UniProt ID: Q13285; Molecular weight: 51kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Steroidogenic Factor 1/SF-1 antibody [EPR19744] (ab217317) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Related Products Conjugation-ready, carrier free format available for antibody clone EPR19744 - ab240394 . Antibody clone EPR19744 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 750 ( ab311023 , ab311149 , ab311792 , ab313075 , ab313270 , ab321391 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
ChIC/CUT&RUN-seq, IHC-P
Platform ID
BAB982862466
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed : 27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed : 27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. See full target information NR5A1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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