Anti-Stromal interaction molecule 1 antibody,Abcam,AB62031

Target data Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane : Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels (PubMed : 15866891, PubMed : 16005298, PubMed : 16208375, PubMed : 16537481, PubMed : 16733527, PubMed : 16766533, PubMed : 16807233, PubMed : 18854159, PubMed : 19182790, PubMed : 19249086, PubMed : 19622606, PubMed : 19706554, PubMed : 22464749, PubMed : 24069340, PubMed : 24351972, PubMed : 24591628, PubMed : 25326555, PubMed : 26322679, PubMed : 28219928, PubMed : 32415068). Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry (PubMed : 16208375, PubMed : 16537481, PubMed : 32415068). Involved in enamel formation (PubMed : 24621671). See full target information STIM1