Anti-Strumpellin antibody,Abcam,AB126109

Host

Rabbit

Reactivity

Human

Application

WB, IHC-P

Platform ID

BAB483612106

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Strumpellin antibody
Cat. No.AB126109
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human WASHC5 aa 900-1150. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed : 19922875, PubMed : 20498093). May be involved in axonal outgrowth. Involved in cellular localization of ADRB2 (PubMed : 23085491). Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (PubMed : 23676666). See full target information WASHC5

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