Anti-Sumo 1 antibody [Y299] - ChIP Grade,Abcam,AB32058
What is this antibody validated in? Anti-Sumo 1 antibody [Y299] - ChIP Grade (ab32058) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), ChIP in Human, Mouse, Rat samples. What is the molecular weight of Sumo 1? Anti-Sumo 1 [Y299] - ChIP Grade (ab32058) specifically detects a band for Sumo 1 (UniProt: P63165) at a molecular weight of 12kDa. Trusted by the scientific community Anti-Sumo 1 [Y299] - ChIP Grade (ab32058) was first used in a scientific publication in 2006 and has been cited over 90 times in peer-reviewed journals. Reviewed by scientists Anti-Sumo 1 [Y299] - ChIP Grade (ab32058) has over 10 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Sumo 1 antibody [Y299] - ChIP Grade (ab32058) has been confirmed by Western blot testing in SUMO1 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [Y299] also available for your convenience: ab32058, Alexa Fluor® 488 - ab196310 , Alexa Fluor® 647 - ab196533 , Carrier free - ab219724 , PE - ab305671 , APC - ab305672 , HRP - ab305673 , Alkaline Phosphatase - ab308937 , Alexa Fluor® 594 - ab310693 , Alexa Fluor® 555 - ab312223 , Alexa Fluor® 568 - ab312712 , Alexa Fluor® 750 - ab321562 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ChIP, IP, IHC-P, ICC/IF, WB, Flow Cyt (Intra)
Platform ID
BAB171605619
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed : 19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed : 24651376). See full target information SUMO1
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