Anti-TAB1 antibody,Abcam,AB245586

Target data Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed : 22307082, PubMed : 24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed : 10838074, PubMed : 25260751, PubMed : 37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed : 11847341, PubMed : 29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed : 14592977). Plays also a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed : 18021073). See full target information TAB1