Anti-TBR1 antibody,Abcam,AB31940

Anti-TBR1 antibody (ab31940) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB. Anti-TBR1 antibody (ab31940) has been cited over 476 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-TBR1 antibody (ab31940) has high sensitivity and specificity. Anti-TBR1 antibody (ab31940) has 31 independent reviews from customers. Anti-TBR1 antibody (anti-HPRT antibody) (ab31940) specifically detects TBR1 (UniProt ID: Q64336; Molecular weight: 74kDa) and is sold in 100 µg selling sizes. TBR1 (T-Box Brain Transcription Factor 1) is a transcription factor that is crucial for brain development, particularly in the formation of the cerebral cortex. It regulates the expression of genes involved in neuronal differentiation and migration. Mutations in the TBR1 gene are associated with neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, where they disrupt normal brain development and function.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

WB, IHC-P

Platform ID

BAB988559730

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-TBR1 antibody
Cat. No.AB31940
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationWB, IHC-P
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection (PubMed : 25232744, PubMed : 30250039). As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons (By similarity). See full target information TBR1

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