Anti-TIPIN antibody,Abcam,AB229329

Host

Rabbit

Reactivity

Human

Application

WB

Platform ID

BAB807013121

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-TIPIN antibody
Cat. No.AB229329
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human TIMELESS-interacting protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed : 17102137, PubMed : 23359676, PubMed : 35585232). Important for cell survival after DNA damage or replication stress (PubMed : 17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed : 17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed : 17102137, PubMed : 17116885, PubMed : 17296725, PubMed : 23359676, PubMed : 35585232). See full target information TIMELESS-interacting protein

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