Anti-TLR9 antibody [26C593.2],Abcam,AB134368

What is this antibody validated in? Anti-TLR9 antibody [26C593.2] (ab134368) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of TLR9? Anti-TLR9 [26C593.2] (ab134368) specifically detects a band for TLR9 (UniProt: Q9NR96) at a molecular weight of 115kDa. Trusted by the scientific community Anti-TLR9 [26C593.2] (ab134368) was first used in a scientific publication in 2012 and has been cited over 20 times in peer-reviewed journals.

Host

Mouse

Reactivity

Mouse, Rat, Human

Application

WB, Flow Cyt (Intra), ICC/IF, IHC-P

Platform ID

BAB183000147

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-TLR9 antibody [26C593.2]
Cat. No.AB134368
HostMouse
IsotypeIgG1
ReactivityMouse, Rat, Human
ApplicationWB, Flow Cyt (Intra), ICC/IF, IHC-P
ClonalityMonoclonal
Clone Number26C593.2
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human TLR9 aa 250 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Key component of innate and adaptive immunity (PubMed : 14716310). TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms (PubMed : 14716310). TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed : 14716310). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed : 11564765, PubMed : 17932028). Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome (By similarity). Plays a role in defense against systemic mouse cytomegalovirus infection (By similarity). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed : 23857366). See full target information TLR9

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