Anti-TMC6 antibody,Abcam,AB67325

Target data Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed : 18158319, PubMed : 30068544, PubMed : 32917726). Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed : 30068544, PubMed : 32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (PubMed : 18158319). Down-regulates the activity of transcription factors induced by zinc and cytokines (PubMed : 18158319). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity). See full target information TMC6